Postdoctoral Fellow in Developmental Epigenetics and Human Disease

 

Employer: Baylor College of Medicine

Location:

Departments of Pediatrics and Molecular & Human Genetics
USDA/ARS Children’s Nutrition Research Center
Texas Medical Center
Houston, TX

Description:

The Waterland laboratory at Baylor College of Medicine (BCM) is making a difference by documenting, at the molecular level, the long-term adverse consequences of poor nutrition during development. Our overarching goal is to provide evidence to individuals and policy makers to improve nutrition of pregnant women, infants, and children worldwide. Join our team! We currently have multiple NIH-funded openings for highly motivated postdoctoral researchers to explore fundamental questions in developmental epigenetics.

The fellow will take a leading role in the design, implementation, and analysis of experiments in humans and mouse models to improve our understanding of how epigenetic development affects risk of disease. Specifically, projects focus on the role of epigenetic dysregulation in cancer and obesity in humans, and mouse models of developmental epigenetics in the brain, related to energy balance and obesity. We are world leaders in understanding how DNA sequence encodes stochastic epigenetic variation (metastable epialleles) and are developing novel approaches to probe cell-type specific epigenetic changes in complex tissues, combining techniques including transgenics, microdissection, fluorescence-activated nuclear sorting, DNA methylation analysis by whole-genome bisulfite sequencing, and transcriptional profiling (RNA-seq). For examples see our recent papers in Genome Biology https://genomebiology.biomedcentral.com/articles/10.1186/s13059-019-1708-1 and Nature Communications https://www.nature.com/articles/s41467-019-13339-3. For more information see https://www.bcm.edu/research/labs-and-centers/faculty-labs/robert-waterland-lab.

We are dedicated to advancing the careers of our trainees, and offer a competitive salary and stimulating work environment with opportunities for advancement. BCM is in the Texas Medical Center, the world’s largest medical center and a vibrant and collaborative research environment. Houston is a large, culturally diverse and thriving metropolis with a relatively low cost of living.

Recent PhDs with strong publications in a relevant discipline will be considered. Individuals already in the US are particularly encouraged to apply. We will also consider outstanding individuals at career stages other than postdoctoral, with relevant experience.

To apply, submit a single PDF containing your CV, statement of research interests, and names and contact information of three references to: Robert A. Waterland, PhD, Baylor College of Medicine; E-mail: waterland@bcm.edu .

Baylor College of Medicine is an equal opportunity / affirmative action / equal access employer.

Key words: bioinformatics, bisulfite-seq, cancer, computational biology, data science, development, developmental origins, developmental programming, DNA methylation, DOHaD, epigenetics, epigenome, epigenomic, exercise, human, hypothalamus, mammalian, metastable epiallele, mouse, neuron, neuroscience, next-generation sequencing, nutrition, obesity, postdoc, physical activity

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